Drop RxJava on Android 4.2.2

After installing the API level at 17 (was 21 ), the application began to fall.

Method where the application crashes:

 private Observable<Notification> createHandleObservable() { return Observable.create(DocumentHandleObservableOnSubscribe.getInstance()) .repeatWhen(observable -> observable.delay(HANDLE_INTERVAL_MIN, TimeUnit.MINUTES)) .observeOn(Schedulers.io()) .subscribeOn(Schedulers.io()); } 

Mistake:

 11-01 20:08:10.025 31944-31944/? E/AndroidRuntime: FATAL EXCEPTION: main Process: com.rostislav.dugin.reminderofwork, PID: 31944 java.lang.NoClassDefFoundError: rx.plugins.RxJavaPlugins at rx.Observable.<clinit>(Observable.java:62) at com.rostislav.dugin.reminderofwork.DocumentHandleService.createHandleObservable(DocumentHandleService.java:58) at com.rostislav.dugin.reminderofwork.DocumentHandleService.onStartCommand(DocumentHandleService.java:32) at android.app.ActivityThread.handleServiceArgs(ActivityThread.java:2868) at android.app.ActivityThread.access$2100(ActivityThread.java:151) at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1418) at android.os.Handler.dispatchMessage(Handler.java:110) at android.os.Looper.loop(Looper.java:193) at android.app.ActivityThread.main(ActivityThread.java:5292) at java.lang.reflect.Method.invokeNative(Native Method) at java.lang.reflect.Method.invoke(Method.java:515) at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:824) at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:640) at dalvik.system.NativeStart.main(Native Method) 

build.gradle :

 apply plugin: 'com.android.application' apply plugin: 'me.tatarka.retrolambda' android { compileSdkVersion 24 buildToolsVersion "24.0.3" defaultConfig { applicationId "com.rostislav.dugin.reminderofwork" minSdkVersion 17 targetSdkVersion 24 versionCode 1 versionName "1.0" multiDexEnabled true } compileOptions { sourceCompatibility JavaVersion.VERSION_1_8 targetCompatibility JavaVersion.VERSION_1_8 } buildTypes { release { minifyEnabled false proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.pro' } } } dependencies { compile fileTree(include: ['*.jar'], dir: 'libs') testCompile 'junit:junit:4.12' compile 'com.android.support:appcompat-v7:24.2.1' compile 'com.android.support:design:24.2.1' compile 'io.reactivex:rxandroid:1.2.1' compile 'io.reactivex:rxjava:1.1.6' compile 'com.android.support:multidex:1.0.1' } 

pro-rules.pro :

 -keepattributes InnerClasses -dontoptimize 

What is the mistake and how to fix it?

UPD_0:

 <?xml version="1.0" encoding="utf-8"?> <manifest xmlns:android="http://schemas.android.com/apk/res/android" package="com.rostislav.dugin.reminderofwork"> <uses-permission android:name="android.permission.INTERNET" /> <uses-permission android:name="android.permission.ACCESS_NETWORK_STATE" /> <uses-permission android:name="android.permission.WRITE_EXTERNAL_STORAGE" /> <application android:allowBackup="true" android:icon="@mipmap/ic_launcher" android:label="@string/app_name" android:supportsRtl="true" android:theme="@style/AppTheme"> <activity android:name=".SettingActivity"> <intent-filter> <action android:name="android.intent.action.MAIN" /> <category android:name="android.intent.category.LAUNCHER" /> </intent-filter> </activity> <service android:name=".DocumentHandleService" /> <receiver android:name=".NotificationShower" /> </application> </manifest>