Sorry, not enough reputation for comment, so I will answer. If you can do "anything" before the search, then what prevents to make a list of hashes of lines of the file? Then the search will be to calculate the hash of the search string and compare it with the list.
You can sort the rows. Then the search will be on this algorithm:
N = 1, M = 1
Compare the character N of the search line with the character N of the line M. If N = N + 1 are equal, repeat step 2, otherwise step 3.
M = M + 1 (go to the next line), compare the characters 1..N of the required line and the line M. If we are equal, repeat step 2, otherwise there is no required line (we interrupt the search).
Add: So as not to compare the initial characters in each line, after sorting, you can attach to each line a number equal to the length of the same number of characters from the beginning of the line. Then in step 3 we check that N-1 <= K (the length of the same segment with the previous line). If N-1> K, then there is no search string.
Example:
0-abvgd (there is no identical section with the previous one)
3-abway (first three characters match)
0-bbbav (no matches)
0-way (no match)
4-dyet (4 first characters match)
Search: "abvgi" In the second step we get to 5 characters. at the third step, N-1> 3, so there is no search string.